Extrapyramidal disorders may be caused by lesions of various parts of the cortico-subcortical systems, which form a single loop motor regulation, and therefore the value of extrapyramidal syndromes topical limited.

For example, Parkinson's syndrome may be caused not only by the defeat of the substantia nigra, but also the defeat of the striatum, Pallidum, or their connections to the frontal lobes. Artane is most often associated with damage to the shell, but may be caused by damage to other ganglia. Chorea often associated with lesions of the caudate nucleus, but is caused by lesions and other ganglia, including the shell or kernel subtalamicheskogo.

Trihexyphenidyl more clearly associated with damage to specific structures (subtalamicheskogo kernel), but it is sometimes called the primary damage to system striatum. Even more complex issues topical diagnosis in the analysis of the origin of tics or tremors. In neurochemical terms of normal Artane dosage provides a balance of neurotransmitter systems: dopamine, cholinergic, glutamatergic, GABAergic, serotonergic in oprededennoy extent, noradrenergic, opiatergicheskih, peptidergic and some others.

Thus, Generic Artane may be related to a violation of the functional balance of different parts of a motor cortical-subcortical range of activities and ensure their neurotransmitter systems.